During the study of the DNA from 25 β-thalassemic subjects from mediterranean origin the polymorphic Taq I restriction site located 3-kb 5’ to the human δ-globin gene, was found non-randomly associated to the polymorphic Hind III sites within the Gγ- and Aγ-globin genes. This indicates that the 3’limit of the linkage group of polymorphic restriction sites including the γ-globin genes is located downstream to the polymorphic Taq I site.

Keywords:
Human globin genes, Polymorphic Taq I site, β-Thalassemia
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© 1984 S. Karger AG, Basel
1984
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