The results of a cytogenetic analysis of peripheral blood cells in a 61-year-old male with histopathologically documented osteomyelosclerosis, hepatosplenomegaly, ascites and anemia are described. The karyotype 46, X,-Y+ 1p22→qter, without Ph1-chromosome, was observed in all unstimulated and in most PHA-stimulated cells. The patient had not received cytostatic or radiation therapy, thus the marker lq+ could not have resulted from such clastogenic treatments.
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© 1984 S. Karger AG, Basel
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