In this study we have correlated the presence/absence of rare red blood cells with HbH inclusions with the α-globin genotype in a group of Sardinian α-thalassemia carriers, whose genotype have been defined by α-globin gene mapping. We found that the majority of the carriers investigated, including those with the deletion of a single or two α-globin genes and those with non-deletion lesions, have rare red blood cells with inclusions, with no significant difference in the frequency of positive finding related to the α-globin genotype.
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© 1984 S. Karger AG, Basel
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