The plasma β2-microglobulin (β2-MG) levels in 118 children with thalassaemia were investigated. The mean level was higher than in healthy children. A significant increase of β2-MG was associated with hypersplenism (3.14 ± 0.6 mg/l). The β2-MG levels appeared to reflect reticuloendothelial system activity but were not related to iron overload. Fibronectin levels were generally lower than in healthy adults; profound chronic fibronectin depletion was not accompanied by an increased liability to infection.

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