Erythrocyte surface sialic acid was measured in 94 full-term new-born infants and in 20 premature infants of different ages, varying from 1 to 16 post-natal days. After the first 3 days of life, the amount of sialic acid, both per cell and per gramme of haemoglobin, was rapidly reduced to 70–80% of the initial value; these lower levels were maintained on the following days. The decrease observed on the 4th day may represent an expression of the mechanism by which a large amount of fetal red blood cells is eliminated from the circulation during the same period. Therefore, the relationship between sialic acid decrement and red cell sequestration exists also in fetal erythrocytes, and this may contribute to clarify the exact role of sialic acid in red cell survival time.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.