The distribution of phenotypes and gene frequencies of the third component of complement (C3) were studied in 106 β-thalassemic patients and in 112 carriers of the β-thalassemia trait. A statistically significant association was found between the C3F gene and homozygous β-thalassemia. It can be suggested that this association may be related with the high incidence of infections encountered in these patients.
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© 1984 S. Karger AG, Basel
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