It has been found possible to test ferritin concentrations in the reticulum and hemopoietic cells from human bone marrow by an immunoradiometric assay. Ferritin concentration in healthy test persons amounts to 0.92 ± 0.38 ng/μg protein in the reticulum and 0.084 ± 0.031 ng/μg protein in hemopoietic cells. In healthy test persons about 90% of the ferritin is localized in the reticulum and about 10% in the hemopoietic cells. The ferritin concentration in the reticulum is decreased in patients having iron deficiency anemia. In these patients only 50–70% of the bone marrow ferritin is localized in the reticulum. Bone marrow ferritin was characterized by a combination of anion-exchange chromatography using Sephadex A-50 and an immunoradiometric assay. Marrow ferritin from healthy persons is eluted at chloride concentrations between 200 and 300 mM. The anion-exchange chromatographic properties of ferritin in the reticulum and hemopoietic cells are identical.

Keywords:
Bone marrow, Ferritin, Hemopoietic cells, Reticulum
This content is only available via PDF.
© 1982 S. Karger AG, Basel
1982
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.