Lymphocytes from 107 healthy individuals and 34 patients with lung cancer were cultured and stimulated with PHA. Wide variation in lymphocyte transformation reactivity was observed, ranging from significantly low responses to high blastogenesis. Low spontaneous blastogenic responses were not always associated with a simultaneous decrease in PHA-induced lymphocyte transformation in the same individuals. The results are presented by the (disintegrations per minute) values of the stimulated and nonstimulated cultures and by the stimulation index. A new index termed the Blastogenic Cumulative Index is proposed. It is defined as the sum of the logarithms of the values of the spontaneous and the PHA-induced lymphocyte transformation. A better relationship was observed in immunocompetent and in immunodepressed individuals between the dpm values and Cumulative Indices than between the dpm and the Stimulation Indices.

Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.