Platelet-rich plasma was incubated with dianhydrogalactitol (DAG) in vitro. This moderately diminished platelet aggregation induced by adrenaline and to a smaller degree by adenosine diphosphate (ADP) or collagen. The availability of platelet factor 3 induced by ADP, adrenaline or collagen was decreased irrespective of the inducer. The release of platelet factor 4 was unaffected. Reptilase clot retraction induced by ADP or collagen was slightly inhibited. Uptake of 14C-serotonin was slightly decreased. Uptake of 14C-adenine was normal. Platelet adhesion onto glass was not depressed. DAG did not release lactic dehydrogenase from the cytoplasm of the platelets. Coagulation factors were not affected.

Keywords:
Dianhydrogalactitol (DAG), Platelet aggregation, Platelet function, Platelet release
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© 1981 S. Karger AG, Basel
1981
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