Haemoglobin synthesis was studied in bone marrow erythroblasts and in reticulocytes of 4 children with β°- thalassaemia major and of 7 children with β+-thalassaemia major. In patients with β°-thalassaemia the γ/α ratio was found to be lower in bone marrow than in peripheral blood. On the contrary, in patients with β+ thalassaemia the β+γ/α ratio was more balanced in bone marrow, where the β-chain synthesis was higher, than in reticulocytes. This last result could be explained by the presence of an abnormal m-RNA for β-chains in β+-thalassaemia.
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© 1981 S. Karger AG, Basel
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