Blood group glycosyltransferases (A and B) in plasma are mainly derived from other tissues, not from bone marrow where the blood group substances are synthesized. Therefore, it is possible to determine the original blood type of host subject and grafted cells by examining the enzyme activity in plasma from a chimera subject. Subject WD had 75–85% of·type cells and 15–25% of A1 type cells. A1 enzyme activity of the subject’s plasma was the same as control A1plasma, suggesting that subject WD is genetically A1O1or A1A1and·red cells are produced by OO bone marrow cells acquired in utero. Another subject EA has about 85% of B type and 15% of A1B type red cells. B enzyme activity of the subject’s plasma is normal, but A enzyme activity is only 20% of normal level. Subject EA must be genetically BO or BB, and A gene is restricted to bone marrow cells acquired.

Keywords:
Blood chimera, Blood group glycosyltransferase, Galactosyltransferase, N-acetylgalactosaminyltransferase
This content is only available via PDF.
© 1980 S. Karger AG, Basel
1980
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.