The authors have investigated the cytokinetic behaviour of 23 cases of non-Hodgkin B cell lymphomas. In all cases diagnosis was established on the basis of histological, cytoimmunological and cytochemical data. The study, carried out with the aid of autoradiographic techniques, indicates that the various histological subclasses are characterized by a different metabolic and kinetic behaviour: the aggressiveness of the malignant lymphoma is closely related to the rate of growth of the lymphomatous cell populations, as assessed by the mitotic index and the labelling index with 3H-thymidine. The study of the synthesis and metabolism of RNA provides not only useful information on the energy requirements necessary for the neoplastic growth, but, when employed in association with immunohistochemical techniques for the detection of intracytoplasmic Ig synthesis, it defines more accurately the functional characteristics and the differentiation potentialities of the neoplastic populations in different cases.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.