In 56 patients with chronic lymphocytic leukemia the value of clinical staging and response to therapy were analyzed. 51 patients were given therapy. Actuarial survival curves for patients who showed a complete or partial remission differed significantly for patients who either improved or in whom therapy failed (p < 0.001). The 5-year survival fraction was significantly better determined by response to therapy than by clinical staging. 5-year survival fraction for stage 0 + I + II was 59%, and for III + IV 27% (not significant, p = 0.08). 5-year survival fraction for patients with failure or only improvement to therapy was 20%, and with complete or partial remission 72% (significant, p = 0.003).

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