The pattern of composition of hemoglobin in different heterozygotes for S and D hemoglobins is quantitatively accounted for by the relative rates of combination of the different chains α + βA > α + βD > α + βs > α + γ.It is suggested that the recombination step may be one of the rate-limiting steps in hemoglobin assembly.
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© 1980 S. Karger AG, Basel
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