The composition of the γ-chains has been examined in 21 fetuses and premature babies and in 18 full-term newborns. Gγ/Aγ ratio was slightly higher in fetuses (0.81 ± 0.04 expressed as glycine residue at position 136) than in full-term newborns (0.73 ± 0.06), while the incidence and the percentage of Tγ-chains were clearly higher in the first group and overlap the values found in the Hb F from β-thalassemia homozygotes. On the basis of these data the authors hypothesize that Tγ/-chains may be codified by a gene more active during intrauterine life than at birth. Possibly, their synthesis may be reactivated when high levels of Hb F are present during adult life, as in β-thalassemia.

Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.