Erythroleukaemia in an elderly Caucasian male was associated with the presence of 15% of haemoglobin H (Hb-H; Hb-β4) in the haemolysate, identified by electrophoretic analysis, isolation and ‘finger-printing’. The peripheral blood picture was dimorphic, with 40% of hypochromic and morphologically abnormal red cells. Inclusion bodies indicative of the presence of Hb-H occurred in 30% of the red cells after supravital staining. The rare occurrence of Hb-H in leukaemic conditions and its distribution in the red cells is discussed in relation to the possible clonal origin of leukaemia and the involvement of red cell precursors.
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© 1978 S. Karger AG, Basel
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