A case of systemic mastocytosis with unusual clinical manifestations, appearing as an isolated splenohepatomegaly, is described. The proliferative character is evident from the cytological characteristics of immaturity and the presence of a moderate percentage of mast cells in the peripheral blood. These cells make up 40%of the total cells in the bone marrow Special attention is given to the optical, morphological, cytochemical, and ultrastructural studies of the disease. Some anomalies were found at the subcellular level which apparently have not been recorded until present Various dyshematopoietic features of this case are reported, which may be considered as manifestations of a paraneoplastic syndrome

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