By means of ferrokinetic investigations three different stages of myelosclerosis can be defined: stage I with shortened plasma iron disappearance half-time, increased plasma iron turnover and normal activities in surface-scanning; stage II with ferrokinetically detectable extrameduUary erythropoiesis and normal utilisation of plasma iron; stage III with ineffective erythropoiesis. This classification seems to correlate better with the clinical course of the disease than the histological staging and, furthermore, seems to have some prognostic relevance.
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© 1976 S. Karger AG, Basel
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