The γ chain in a Ghanaian homozygous for hereditary persistence of fetal haemoglobin was considered to be of the Gγ type on the basis of the amino acid analysis of γ Tp XIV (γ133–144) of the Hb F of this subject . Recently, the sequence of residues γ134–137 of the γ-chain of this subject was determined and found to contain some alanine at position γ136. It is therefore of the Gγ + Aγ type. A rapid technique for the isolation of γ CB-3 (γ l34–146) peptides in human fetal haemoglobin for Gγ;Aγ ratio determination is described.
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© 1975 S. Karger AG, Basel
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