The enzymes of blood and marrow neutrophils can be used to aid in the determination of the cell’s maturity. The enzyme marker which signals the production of secondary granules, leukocyte alkaline phosphatase (LAP), was found to be inactivated by aldehyde fixation, but minimal fixation of cells gave adequate marphological preservation and good enzyme activity. Notably, LAP activity was found to be present in neutrophils from the marrow myelocyte stage to the blood neutrophil stage, and high levels were found in the synthetic organelles of some circulating matureneutrophils. These observations at the electron microscopic level confirm the classical light microscopic histochemical findings.

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