In patients with various disorders of haemostasis and in 13 controls we studied the capillary permeability to human 99Tc-albumin. In 16 haemophiliacs, in 2 afibrinogenaemics and in 1 out of 3 patients with von Willebrand’s disease with a factor VIII level of about 15% we observed a marked increase of capillary permeability. On the contrary, 2 patients with a congenital lack of factor V, 2 cases of von Willebrand’s disease with a factor VIII level of about 50% and 3 subjects with ITP showed a normal capillary permeability. The administration of a single small dose of factor VIII (1 U/kg) or IX (2 U/kg) or fibrinogen (15 mg/kg) which did not improve the clotting disorder corrected the permeability for at least 3 days. The induction of a severe clotting disorder by heparin administration in man and by anticoagulant treatment in rabbits did not change the capillary permeability. These results support the hypothesis that antihaemophilic factors and fibrinogen could be involved in the composition and functions of the vascular wall.