An experimental system was designed to search for the presence of factors in the serum of patients with chronic lymphatic leukaemia (CLL) which might affect the viability of the lymphocytes. Washing was found to remove immunoglobulin from the surface of the lymphocytes. In the presence of autologous serum or washings from the leukaemic lymphocytes cell viability was higher and RNA synthesis lower than in cultures with mixed human serum. The factor maintaining cell viability could be adsorbed onto washed leukaemic cells with removal of the effect from the serum. It is suggested that a factor is present in the sera which maintains the leukaemic population in the presence of an intact cellular immune capacity.

Keywords:
Cell surface factor, Immunoglobulins, Lymphatic leukaemia, Lymphocyte viability, Serum enhancing factor
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© 1974 S. Karger AG, Basel
1974
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