Combined cytophotometric-autoradiographic investigations of erythropoiesis in refractory anaemia with hypercellular bone marrow showed a decreased percentage of DNA synthetizing basophilic and polychromatic erythroblasts with an increase of the percentage in G1 In some cases an additional increase of the percentage in G2, respectively a decreased S:G2 ratio was found. The disturbance of cell proliferation is one factor leading to an ineffective cell production but was not found in 3 of the 10 patients with refractory anaemia.
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© 1974 S. Karger AG, Basel
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