The DNA replication patterns previously described in normal human lymphocytes cultured in vitro have also been observed in the peripheral blasts of acute leukemia patients. In 6 ALL cases, the labeling index had a mean value of 4.5% and the 3 patterns of labeling showed a distribution very similar to that found in normal lymphocytes stimulated by PHA. On the contrary, in 11 AML cases, the labeling index presented a mean value of 13.9% with an increase of phase I labeling pattern in most but not all cases. From these data, we suggest that the DNA synthesis of peripheral blast cells is in most cases of AML much slower than in ALL.

Keywords:
Autoradiography, DNA synthesis, 3H-thymidine incorporation, Leukemic cell cycle
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© 1974 S. Karger AG, Basel
1974
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