The study reports on the 59Fe incorporation in the marrow of various bones of mice under ‘normal’ conditions and after acute sublethal whole body irradiation with X- and γ-rays. The decrease of incorporation varies for the different regions of the skeleton in the first few days after irradiation. The total incorporation in different skeletal parts exhibits statistically significant changes, when compared with the pre-irradiation stage. A smaller decrease may be observed in the short spongiose bones, the greatest decrease was found in the femur, humerus, tibia/fibula and pelvis. From the practical point of view, it is important that according to post-irradiation 59Fe incorporation, the femur and tibia, currently used in experiments, are the most ‘reactive’ bones. This should be taken into account when extrapolating data obtained from these bones to the whole bone marrow of a mouse.