Factor XIII levels are within the normal range in patients with pathological fibrinolysis and remain unchanged in the intense fibrinolytic state induced by streptokinase infusion. Incubation of plasma with streptokinase in vitro results in lysis of fibrinogen as shown by a rise in the titre of fibrinogen degradation products, but levels of factor XIII remain normal. Lysis of clot with factor XIII trapped within it, allows almost complete recovery of the factor XIII contained in the clot. It is concluded that plasmin does not destroy factor XIII.
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© 1974 S. Karger AG, Basel
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