The results of a study of 13 families with von Willebrand’s disease, living in a small zone in the province of Vicenza are reported. 21 patients presented all diagnostic signs, while 25 showed only some of them. The aspirin tolerance test gave positive results in 7 out of 10 patients with initially normal bleeding time. Platelet aggregation studies, intended to establish the ‘threshold concentration’ of ADP and adrenaline, showed an impairment of adrenaline aggregation in 5 out of 17 patients.
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© 1974 S. Karger AG, Basel
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