Folate deficiency in four patients could be ascribed to anticonvulsant therapy with phenytoin. Their intestinal absorption of folic acid was depressed only when phenytoin was given simultaneously. Otherwise the absorption of folic acid was normal. This malabsorption of folic acid is probably due to a rise in the jejunal pH produced by phenytoin. It is assumed, however, that this effect of phenytoin is rather the result than the cause of folate deficiency occurring during anticonvulsant drug therapy.
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© 1974 S. Karger AG, Basel
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