The effect of fibrinogen/fibrin degradation products (FDP) on the stabilisation of fibrin was tested in vitro by the clot solubility assay and by the transamidase assay of 14C-glycine-ethyl-ester incorporation into casein. No significant interference with the action of factor XIII by FDP was demonstrated. FDP, prepared in vitro, could act as substrate for factor XIII although compared with casein FDP are a poor substrate. Patients with high titres of FDP in their sera form normal insoluble clot. Defective fibrin stabilisation does not appear to be important in the bleeding diathesis seen in disseminated intravascular coagulation, even though both high titres of FDP and low levels of factor XIII are found.

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