The effect of fibrinogen/fibrin degradation products (FDP) on the stabilisation of fibrin was tested in vitro by the clot solubility assay and by the transamidase assay of 14C-glycine-ethyl-ester incorporation into casein. No significant interference with the action of factor XIII by FDP was demonstrated. FDP, prepared in vitro, could act as substrate for factor XIII although compared with casein FDP are a poor substrate. Patients with high titres of FDP in their sera form normal insoluble clot. Defective fibrin stabilisation does not appear to be important in the bleeding diathesis seen in disseminated intravascular coagulation, even though both high titres of FDP and low levels of factor XIII are found.

Keywords:
Bleeding disorders, Disseminated intravascular coagulation, Factor XIII, Fibrin degradation products, Fibrin stabilisation
This content is only available via PDF.
© 1974 S. Karger AG, Basel
1974
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.