A 7-year-old black American boy with severe hypochromic anemia, mild hepatomegaly, and reticulocytosis had a persistent and rather severe epistaxis which was in part responsible for the anemia. Electrophoretic, chromatographic, and chemical analyses indicate the simultaneous occurrence of Hb S and Hb G Georgia or α2(95 Pro(→Leu) β2. The father is a Hb S heterozygote and the mother a Hb Gαheterozygote. Quantitative analyses of the patient’s hemoglobin show the presence of about 15% αG containing hemoglobins and about 36% βscontaining hemoglobins which is about the same as is observed in a Hb S trait individual.
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© 1974 S. Karger AG, Basel
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