A 66-year-old man presented with moderately severe hemolytic anemia. Hematologic and biochemical evaluation proved him to have a hitherto undescribed variant of erythrocyte glucose-6-phosphate dehydrogenase. Glucose-6- phosphate dehydrogenase Jackson is characterized chiefly by chronic hemolysis in the absence of ‘oxidant’ drugs or infection, markedly reduced enzyme activity and variations in substrate affinity. In addition, the patient had leukopenia and thrombocytopenia, possibly resulting from stem cell competition due to the marked demand for erythropoiesis.
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© 1974 S. Karger AG, Basel
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