Equivalent hemolysis was produced in adult albino rats by intracardiac injection of copper sulfate phenylhydrazine and antiserum. Reticulocyte response and hemoglobin formation were studied in relation to splenic erythrophagocytic activity, hepatic erythrophagocytosis, and evidence of intravascular hemolysis. Splenic feedback produced an early, rapid reticulocyte response when accompanied by a fall in the hemoglobin levels, whereas hepatic erythrophagocytosis and intravascular breakdown produced a slower response.
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© 1974 S. Karger AG, Basel
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