Lysozyme-negative, peroxidase-positive (L-, P+) cells are small mononuclear cells, which were found to constitute 3.4+1.3% (mean+SD) of the leukocytes in normal rat blood. When tritiated thymidine was injected into rats at 6-hour intervals for 5.5 days, a maturation time of 3–4 days preceded he appearance of the first labelled L-, P+ cells in the blood. Unlabelled and heavily labelled L-, P+ cells left the circulation at random with a half-time of 28- 31 h. Both the percentage of labelled cells and the grain count data showed that the L-, P+ cells are a uniform cell population differing kinetically from all previously known blood cell populations.

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