Red cells coated with anti-Rho antibody (IgG) were extensively ingested by human blood monocytes and macrophages and only rarely by neutrophils. The erythrophagocytosis was inhibited by free IgG1 and IgG3. Less inhibition occurred with IgG2 and IgG4 indicating that the mononuclear receptor was specific for IgG1 and IgG3. During cell culture, the ability of monocytes to ingest anti-Rho-coated red cells increased to the degree of that of pleural and peritoneal macrophages.
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© 1974 S. Karger AG, Basel
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