After sublethal irradiation, an immature lymphoid cell type with characteristic ultrastructure was found in the bone marrow and thymus of adult mice of different strains. Normally this cell type has only been detected in the embryo or new-born. Grafting normal, adult bone marrow suppresses, while thymectomy enhances the proliferation of these cells in the irradiated organism. Immunologic and functional tests suggest that the cells have either an embryonic origin, or are derivatives of haemopoietic stem cells and function either as precursors for the immunocompetent B and T cells, or in an entirely different lymphoid system.

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