In mixed cryoglobulinemias, peculiar antigenic determinants of the IgG component were shown. Furthermore, in some mixed IgA-IgM-IgG cryoglobulinemias, we have found in the IgA component an anti-IgM activity. These results suggest the presence of antibodies against new antigenic determinants which appear on immunoglobulin molecules following their reaction with the specific antigen. Further evidence for this hypothesis is supplied by the study of cryoprecipitates isolated from hyperimmune animal sera; in these, we have demonstrated, in addition to the antigen used for the immunization, antibody activity against both this antigen and the animal’s IgG.
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© 1974 S. Karger AG, Basel
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