The iron content in the organs of normal, anaemic, and iron-overloaded rats was determined. The urinary iron excretion was not different in anaemic rats compared with normal rats. It was significantly increased in overloaded rats in comparison with normal rats. The iron decrease in liver, spleen, brain, kidney, and muscle in highly anaemic rats was significant, while the iron increase in liver, heart, and muscle in iron-overloaded rats was evident in comparison with normal rats. After treatment with desferrioxamine, the iron content of the organs was decreased in normal rats but not in anaemic or overloaded rats. The removal of iron in overloaded rats seems to be difficult.

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