14C-thymidine incorporation and cytotoxicity to a target cell were used to assess response of peripheral blood leucocytes from patients during the course of acute myeloid leukaemia. Studies were made after mixed culture with allogeneic lymphocytes and stimulation by mitogens. The leukaemic cells were found to respond to both types of stimulus but, just prior to relapse, a fall in reactivity following mixed culture was observed whereas response to mitogens at this time was usually enhanced. The leukaemic leucocytes were found to provoke both marked cytotoxicity and significantly increased 14C-thyιmidine uptake in normal lymphocytes after mixed culture. The degree of reactivity provoked altered during the course of the disease.
This content is only available via PDF.
© 1974 S. Karger AG, Basel
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.