In hemolytic anemia, acute hemorrhagic anemia and β-thalassemia, transformation of stem cells into morphologically identifiable, red cell precursors, already yields, in part, smaller erythroblasts during a brief G1-phase. The interphasic RNA influx into the cytoplasm is increased in hemolytic and hemorrhagic anemias and diminished in β-thalassemia. In hemolytic anemia and acute hemorrhagic anemia, interphasic hemoglobin synthesis occurs in young erythroblasts as in normal erythropoiesis; it is reduced to one-half in thalassemia. In the cases examined, the ‘critical hemoglobin concentration’ is lower in the G2-phase erythroblasts than in normal erythropoiesis, and frequently reached in young erythroblasts. Thus, the number of maturation stages is reduced.

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