Decreased actinomycin D binding was observed in the marrow cells of some patients with chronic myeloid leukaemia. Blast uptake was still reduced in 2 cases of blast crisis and in acute myeloblastic leukaemia. However, the differentiating cells in blast crisis, i.e., those that had passed the blast stage, had exactly the same actinomycin D binding values as normal myeloid cells. After 0.5 mg/kg methotrexate, increased actinomycin D binding on the part of the entire leukaemic population was observed in one case of acute myeloblastic leukaemia. These findings suggest differences in chromatin behaviour and genetic activity in myeloid cells in the different stages of myeloid leukaemia.

Keywords:
Actinomycin binding, Blastic crisis, Genetic regulation, Methotrexate, Myeloid cells, Myeloid leukaemia
This content is only available via PDF.
© 1974 S. Karger AG, Basel
1974
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.