Bone marrow cells of 8 patients with acute lymphocytic leukemia were studied by cytochemical and autoradiographic methods for the synthesis of nucleic acids in the presence or absence of L-asparaginase. The cultures included thymidine for DNA or uridine for RNA metabolism. In the absence of the enzyme the leukemic lymphoblasts reacted more intensely for DNA and RNA synthesis. The addition of the enzyme revealed depressed incorporation of the labeled precursors by the primitive cells
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© 1973 S. Karger AG, Basel
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