The effect of L-asparaginase on various acute human lymphoblastic leukemia cell populations was evaluated in an investigation of its mechanism of action with respect to the blast cell cycle and the growth of the leukemic cell population. Immediately following the injection of the drug, the number of cells in S increased, while those in G2 and M decreased. The percentage in G2 showed no appreciable change. Later a destructive effect of L-asparaginase on cells in S phase was noted, together with reduction of the size of the proliferating compartment. Reference is made to recently proposed proliferation kinetic models in acute leukemia in support of the view that the action of the drug may also be directed towards cells in transition from G₀ to G1

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