The effect of L-asparaginase on various acute human lymphoblastic leukemia cell populations was evaluated in an investigation of its mechanism of action with respect to the blast cell cycle and the growth of the leukemic cell population. Immediately following the injection of the drug, the number of cells in S increased, while those in G2 and M decreased. The percentage in G2 showed no appreciable change. Later a destructive effect of L-asparaginase on cells in S phase was noted, together with reduction of the size of the proliferating compartment. Reference is made to recently proposed proliferation kinetic models in acute leukemia in support of the view that the action of the drug may also be directed towards cells in transition from G₀ to G1

Keywords:
Asparaginase, Autoradiography, Cell cycle, Cytospectrophotometry, Leukemia therapy, Lymphoblastic leukemia
This content is only available via PDF.
© 1973 S. Karger AG, Basel
1973
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.