A case of platelet factor 3 deficiency (thrombocytopathy) is presented. The coagulation study showed a normal plasmatic pattern but a defective prothrombin consumption. The thromboplastin generation was defective too and was corrected by the substitution of the patient’s platelets with normal platelets or with a platelet substitute. The platelet factor 3 availability was abnormal. On the contrary, platelet adhesiveness to glass and ADP, adrenaline or collagen-induced platelet aggregation were normal. The parents and a sister of our propositus presented a normal coagulation pattern
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© 1973 S. Karger AG, Basel
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