The effect of a proliferation-independent (nitrogen mustard) and 4 proliferation-dependent (methotrexate, vinblastine, cyclophosphamide and 5-fluorouracil) cytotoxic agents has been investigated, concurrently, on the 3 in vivo assays (colony-forming units, erythroid repopulating ability and granulocytic repopulating ability) for haemopoietic tem cells. These preliminary results show that the proliferation-dependent agents produce different responses in the 3 assays consistent with the presence of 3 different cell populations proliferating at different rates. The findings tend to support published hypotheses on the existence of 3 different stem cell populations (possibly ‘committed’ stem cells)

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