Following the failure to discover significant factor VIII and IX levels in a 14-week male fetus, from a pregnancy terminated because the mother was a known carrier of Christmas disease, these factors were measured in 10 other apparently normal fetuses. In no case was the level above 1%. Factors VIII and IX, therefore, do not to be synthesised in early pregnancy, so itis not possible to differentiate normal from haemophilia and Christmas disease males by present techniques during the early stages of pregnancy when termination would be acceptable.
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© 1973 S. Karger AG, Basel
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