In 74 adults with serum B12 Z. 140 pg/ml with or without anaemia, unsaturated B12-binding capacity (UBBC), total B12-binding capacity and transcobalamin I and II (TC I, TC II) were determined using 57Co B12. The results were statistically analysed in relatíon to severity of anaemia and vitamin B12 deficiency. In severe vitamin B12 deficiency, TC II was reduced and contributed to the reduction of UBBC. Greater unsaturation and moderate increase in total TC I were also seen. It is suggested that anaemia is a contributory factor in the moderate increase of TCI. On the basis of limited evidence presently available, it is argued that abnormal intestinal structure and function associ; ciency may result in impaired synthesis of TC II.

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