Components of the fibrinolytic enzyme systern were measured in 40 patients with malignant lymphomas. Fibrinolytic activity, as assessed by the euglobulin clot lysis time, was reduced in the majority of patients. The mean fibrinogen level was elevated in patients with Hodgkin’s disease and reticulum cell sarcoma. Four patients in the terminal phase of their illness had a marked reduction in plasminogen. α1-Antitrypsin and serum activation inhibitor levels were increased; α2-macroglobulin levels were normal. No patient had conclusive evidence of disseminated intravascular coagulation.
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© 1973 S. Karger AG, Basel
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