In 3 patients with myeloma and paraprotein containing cells in the peripheral blood, we demonstrated by an immunofluorescent technique an increase in the number of lymphocytes and plasma cells with immunoglobulin determinants of paraprotein class specificity. Lymphocytes found with mebranous and intracytoplasmic paraprotein content were considered as intermediate forms in plasma cell development. Some possible disturbances of cell proliferation known in lymphoproliferative diseases are discussed.
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© 1973 S. Karger AG, Basel
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