Equivalent hemolysis was produced, after 24 h, in adult albino rats, by the intracardiac injection of copper sulphate, phenylhydrazine and antiserum. The erythrophagocytic count was done on sections of the spleen and compared with the release of Perl’s within the splenic reticuloendothelial cells (REC). From the results obtained it is concluded that iron is released within the splenic REC after erythrophagocytosis while the hemoglobin spilt directly into the plasma is not processed by these cells. The activity of the REC varies with the agent, copper sulphate giving rise to a rapid release of iron whereas phenylhydrazine and antiserum produce a slower activity.
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© 1972 S. Karger AG, Basel
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