On the basis of ultrafiltration experiments, it is demonstrated that the binding of folic acid to plasma depends on pH. When pH is plasma protein binding of folic acid decreases. 7.4, approximately 50% of plasma folic acid is bound to plasma proteins, predominantly albumin. No carrier protein other than albumin was detected. The binding of folic acid to plasma proteins is not reduced by barbital sodium. Paper electrophoresis was found unreliable in the investigation of folic acid binding to plasma proteins.
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© 1972 S. Karger AG, Basel
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